Can robots and humans make babies together? This is a serious
question inspired by some of the advances already achieved in the 21st
century by researchers in cell biology and in a discipline variously
known as biorobotics, synthetic biology, or bionanotechnology.
Although it had long been a truth universally acknowledged that
sexual intercourse was an essential precursor to conception, it was only
around 150 years ago that early studies of embryology revealed the
reason why, according to the dogma of the time, intercourse was
“essential” in human reproduction. The reason was that only an egg from
a female, fertilized by a sperm from a male, can result in a live
birth. But thanks to the Nobel prize winning work of researchers like
embryologist John Gurdon and stem cell researcher Shinya Yamanaka, it
has become possible during the past few years to create both sperm cells
and eggs in the laboratory from skin cells, obviating the need for a human mother or father to kick off the reproductive process.
It has become possible during the past few years to create both sperm cells and eggs in the laboratory from skin cells. At
the end of April 2016, Stanford University and the Valencia Infertility
Institute announced the result of a collaboration project in which
human sperm, with tails, were created from skin cells. Just five months
later, testifying to the speed with which stem cell research is
progressing, researchers at the University of Bath reported that they
had discovered a method of creating offspring
without the need for a female egg. This was heralded as a major
breakthrough which rewrites 200 years of biology teaching, and could
pave the way, for example, for a baby to be born from the DNA of two
men.
In August 2017, researchers at Ohio State College of Engineering announced
an exciting new technology. “Tissue nanotransfection” (TNT for short)
which enables injured or aging tissue to be repaired or restored,
including blood vessels, nerve cells and entire organs.
TNT technology has two major components: First is a
nanotechnology-based chip designed to deliver cargo to adult cells in a
live body. Second is the design of specific biological cargo for cell
conversion. TNT doesn’t require any laboratory-based procedures and is
also non-invasive.
“By using our novel nanochip technology, injured or compromised
organs can be replaced. We have shown that skin is a fertile land where
we can grow the elements of any organ that is declining,” writes the
study’s co-lead, Dr. Chandan Sen, director of Ohio State’s Center for Regenerative Medicine & Cell Based Therapies. The next step for the Ohio researchers is clinical trials next year to test this technology in humans.
In fraction of a second, TNT injects genetic code into the skin,
turning those cells into other types of cells required for treating
diseased conditions, generating any cell type of interest for treatment
within the patient’s own body. This is key to the concept of a
human-robot baby whose genetic information comes from both “parents,”
the robot as well as the human. The skin cells used to derive the sperm
and egg which start the embryonic process, already contain genetic
information from the human parent. But what of genetic information
derived from the robot parent?
Robot genes
To answer this question, let us consider the research of a South
Korean team lead by Jong-Hwan Kim, a pioneer in robotics. In 2005, Kim
and his team at the Robot Intelligence Technology Lab in Korea’s
Advanced Institute of Science and Technology (KAIST) published a paper
in which they describe an artificial creature called Rity, living in a
virtual world. They used Rity to test the world’s first robotic
chromosomes—a set of computerized DNA codes for creating artificial
creatures that can have their own personality, and can ultimately
reproduce their own kind or even evolve as a distinct species. The
effectiveness of the Korean team’s artificial chromosomes was
demonstrated by implanting genetic code into two Rity robots living in a
virtual world, in order to specify their personality.
In 2007, the
Korean team applied for a patent for their “genetic robot” invention.
The patent describes in some detail how the research team model their
software robot based on established biological inheritance laws,
including those propounded by Gregor Mendel, who lived from 1822 to
1884, the founding father of the modern study of genetics.
When a sperm and egg meet, their respective DNAs combine so that half
of our DNA comes from our mother and half from our father. We need to
understand how the Korean model operates in order to understand how a
human-robot baby can be created with genetic codes derived partly from a
robot. The team define their “genetic robot” as an artificial creature,
a software robot, or a general robot that has its own “genetic codes,”
the genetic code of a robot being a single robot genome composed of
multiple artificial chromosomes.
A Korean invention allows the user to design a genetic code for a software robot easily and intuitively. The
genetic codes are classified into “personality genes” related to the
internal state of the software robot, and “outward genes” related to its
outward appearance. The outward genes provide pieces of outward genetic
information that determine the outward appearance of the software
robot, such as its face and its eyes. The personality genes provide
fundamental genetic information, internal state genetic information, and
behavior determination genetic information, and they dictate the
robot’s personality by determining changes in its internal states,
including changes in the robot’s motivations, its homeostasis, and its
emotions, and changes in the corresponding behaviour manifestations as
the robot interacts with its external environment.
The term “fundamental genetic information” refers to fundamental
parameters, for example volatility, which have a great effect on changes
to the robot’s internal states and external behaviours. The internal
state genetic information comprises parameters that affect the internal
state of the robot in relation to how it is affected by external inputs
to the robot. The behavior determination genetic information refers to
parameters that determine the robot’s external behaviours based on its
current internal states.
So to summarize
their invention, the multiple artificial chromosomes implanted in the
Korean software robot dictate the individual personality characteristics
peculiar to that robot, which in turn governs how the robot’s internal
states change, including its motivation, homeostasis, emotion, and its
behavior resulting from those changes while it is interacting with its
external environment.
The Korean team’s patent application also summarizes their method for
passing on genetic information from a robot “parent” to its robot
“offspring.” The genetic codes of one or more software robots are used
as the genetic codes of a pair of parent software robots, and new
genetic information is created by combining genetic information from
paired homologous chromosomes – information provided by the genetic
codes of the parent software robots. The combining is conducted
according to a predetermined gene crossover rule.
The Korean invention allows the user to design a genetic code for a
software robot easily and intuitively and to design genetic codes for
various software robots by crossover. It also enables a user to easily
modify or construct a genetic code for a software robot by providing
both a changing function for intuition traits and a software robot
crossover function. This exercise in genetic engineering is used to
create software robot offspring with the desired personality features.
It cannot be a huge step to translate the genetic code format
generated by the Korean algorithm, into the genetic code format employed
in the Ohio TNT chip, thereby allowing researchers to specify
personality traits and physical characteristics to be passed from a
robot parent to a human-robot baby.
Robot-human offspring
The
very real possibility has appeared of the robots of the future
manipulating human skin cells to create human sperm and human eggs. Suddenly
the very real possibility has appeared on the horizon of the robots of
the future manipulating human skin cells to create human sperm and human
eggs, and from them, using the Ohio discovery of TNT as the basis,
creating an entire human-robot baby whose embryo can be nurtured and
carried through pregnancy by a mother surrogate. By injecting genetic
code into skin cells à la TNT, the Ohio researchers have paved the way
for the genetic code of a robot, containing some of the characteristics
of the robot, to be passed on to its offspring along with human genetic
code. This is how I believe it will be possible, within the foreseeable
future, for humans and robots to make babies together.
Will this happen
in my lifetime? Probably not, as I am 72. But given the phenomenal rate
of discovery and progress in the fields of cell biology and
nanotechnology, I think it is likely to happen before the end of this
century.
There are all sorts of ethical questions relating to such a use of genetic engineering as part of the process to create babies.
These implications were put somewhat into perspective in a post on human genetic engineering
by Renuka Sivapatham, a graduate student at the University of Southern
Denmark. DNA editing techniques have been available for decades and are
crucial tools for understanding gene functions and molecular pathways.
Recently, genome editing
has stepped back into the limelight because of newer technologies that
can quickly and efficiently modify genomes by introducing or genetically
correcting mutations in human cells and animal models.
Genome editing technologies have come a long way and have already advanced towards mammalian models and clinical trials in humans.
These results force scientists to question the future and the
implications of such powerful technology. Should we accept the genetic
engineering of human embryos? If yes, when and in what capacity should
we accept it?
There are all sorts of ethical questions relating to such a use of genetic engineering as part of the process to create babies. Prominent
scientists in the field have already initiated conversations regarding
the ethical implications that arise when modifying the human genome.
Preventing genetic diseases by human genetic engineering is inevitable.
The slippery slope is if, and when, we start to use it for cosmetic
changes such as eye color or for improving a desired athletic trait. A
perfect example is surgery, which we have performed for hundred years
for disease purposes and is now widely used as a cosmetic tool. Opening
the doors for the genetic engineering of human embryos could, with time,
lead to genetic manipulation for desirable traits, raising the fear of
creating a eugenic driven human population.
Who are we to manipulate nature? For those who suffer from genetic
diseases, the answer is not so simple. If we can safely prevent severe
genetic diseases and create healthy humans, why not manipulate nature?
At this time the long-term effects of genome editing remain unknown,
raising additional questions. As the field progresses, with appropriate
regulations and guidelines, it will eventually co-exist alongside other
major controversial topics like nuclear power and genetically modified
organisms. Since ethics are different across the world, creating
international guidelines will be a challenge, but a necessity. Strict
regulations are in place for nuclear power, the same should be possible
for the genetic engineering of human embryos. To outlaw genetic
engineering entirely will be potentially declining a place at the
discussion table, as the further utilization of such technologies is
unlikely to be abandoned.
Excerpted from “Can Robots and Humans Make Babies Together?”,
keynote speech of the third International Congress on Love and Sex with
Robots, delivered in London on Dec. 20.
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